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<!DOCTYPE html>
<html lang="en">
<head>
  <meta charset="UTF-8">
  <meta name="viewport" content="width=device-width, initial-scale=1.0">
  <title>DIGIFab - Patient Education Opportunity</title>
  <style>
    body {
      margin: 0;
      padding: 0;
      font-family: sans-serif;
      display: flex;
      align-items: center;
      justify-content: center;
      height: 600px;
      overflow: hidden;
    }
    .container {
      width: 160px;
      height: 600px;
      display: flex;
      flex-direction: column;
      align-items: center;
      padding: 10px;
      box-sizing: border-box;
      border: 1px solid #ccc;
      overflow: hidden;
    }
    .logo {
      width: 100%;
      height: auto;
      margin-bottom: 10px;
    }
    .content {
      display: flex;
      flex-direction: column;
      line-height: 1.2;
      margin: 0;
      padding: 0;
      font-size: 10px;
      width: 100%;
      overflow: hidden;
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    .heading {
      font-weight: bold;
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      color: #014757;
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    .subheading {
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      color: white;
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      border: none;
      border-radius: 3px;
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      text-align: center;
      margin-top: 5px;
      font-size: 10px;
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      text-overflow: ellipsis;
      width: 100%;
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    .scrolling-box {
      padding: 5px;
      margin-top: 10px;
      border: 1px solid #ccc;
      height: 300px;
      overflow-y: auto;
      font-size: 9px;
    }
    .scrolling-box p,
    .scrolling-box ul {
      margin: 0;
      padding: 0;
    }
    .scrolling-box ul {
      padding-left: 15px;
    }
  </style>
</head>
<body>
  <div class="container">
    <img class="logo" src="https://serb.com/wp-content/uploads/2022/09/SERB-logo-200x57-1.svg" alt="SERB Logo">
    <div class="content">
      <p class="heading">Patient Education Opportunity!</p>
      <p class="subheading">Recognize Digoxin Toxicity</p>
      <p class="text">This patient is on digoxin. Watch for toxicity due to drug interactions, organ function changes, or dehydration. Symptoms include nausea, vomiting, and arrhythmias. Click to Learn More:</p>
      <a href="https://digifab.health/en-us/digoxin-toxicity/early-recognition.html" class="button">Learn More</a>
      <p class="text">For full Prescribing Information, <a href="https://digifab.health/getmedia/f821face-fe6e-4105-8090-5b81816942f0/DigiFab-PI_P12011E_A4-Updated-June2017.pdf">click here</a></p>  
      <p class="text" align="right"><small>US-DGF-2400033</small></p>
    </div>
    <div class="scrolling-box">
      <p><strong>INDICATIONS AND USAGE</strong></p>
      <p>DIGIFab is indicated for the treatment of patients with life-threatening or potentially life-threatening digoxin toxicity or overdose, including:</p>
      <ul>
        <li>Known suicidal or accidental consumption of fatal doses of digoxin: 10 mg or more in adults, or 4 mg in children, or ingestion that causes serum concentrations ≥10 ng/mL;</li>
        <li>Chronic ingestions causing serum digoxin concentrations >6 ng/mL in adults or 4 ng/mL in children;</li>
        <li>Life-threatening toxicity such as severe arrhythmias, progressive bradycardia, or high serum potassium levels with signs of toxicity.</li>
      </ul>
      <p><strong>IMPORTANT SAFETY INFORMATION</strong></p>
      <p>Warnings and Precautions:</p>
      <ul>
        <li>Consider toxic effects of other drugs if symptoms are not relieved by DIGIFab.</li>
        <li>Monitor for rapid drops in serum potassium concentration.</li>
        <li>Monitor cardiac function and provide additional support if needed.</li>
        <li>Anaphylaxis and hypersensitivity reactions are possible. Monitor for signs and treat immediately if they occur.</li>
        <li>Patients with known allergies to sheep protein or previous exposure to Fab are at risk for anaphylactic reactions.</li>
        <li>Do not administer to patients with a known history of hypersensitivity to papaya or papain unless benefits outweigh risks.</li>
        <li>Monitor patients with severe renal failure for prolonged periods for possible recurrence of toxicity.</li>
      </ul>
      <p><strong>Laboratory Tests</strong></p>
      <ul>
        <li>DIGIFab may interfere with digitalis immunoassay measurements. Obtain serum digoxin samples before administration if possible.</li>
        <li>Total serum digoxin concentration may rise after administration, but it will be bound to Fab fragment and not reactive with receptors.</li>
      </ul>
      <p><strong>Adverse Reactions</strong></p>
      <ul>
        <li>Common adverse reactions (>7%) include worsening congestive heart failure, hypokalemia, and worsening atrial fibrillation.</li>
      </ul>
      <p>For full Prescribing Information, <a href="https://digifab.health/getmedia/f821face-fe6e-4105-8090-5b81816942f0/DigiFab-PI_P12011E_A4-Updated-June2017.pdf">click here</a>.</p>
      <p>June 2017</p>
    </div>
  </div>
</body>
</html>

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