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IMPORTANT SAFETY INFORMATION AND INDICATION
</span><br> ARESTIN® (minocycline HCl) is contraindicated in any patient who has a known sensitivity to minocycline or tetracyclines. Hypersensitivity reactions and hypersensitivity syndrome that included, but were not limited to anaphylaxis, anaphylactoid reaction, angioneurotic edema, urticaria, rash, eosinophilia, and one or more of the following: hepatitis, pneumonitis, nephritis, myocarditis, and pericarditis may be present. Swelling of the face, pruritus, fever and lymphadenopathy have been reported with the use of ARESTIN. Some of these reactions were serious. Post-marketing cases of anaphylaxis and serious skin reactions such as Stevens Johnson syndrome and erythema multiforme have been reported with oral minocycline, as well as acute photosensitivity reactions.<br> THE USE OF DRUGS OF THE TETRACYCLINE CLASS DURING TOOTH DEVELOPMENT MAY CAUSE PERMANENT DISCOLORATION OF THE TEETH, AND THEREFORE SHOULD NOT BE USED IN CHILDREN OR IN PREGNANT OR NURSING WOMEN.<br> Tetracyclines, including oral minocycline, have been associated with development of autoimmune syndromes including a lupus-like syndrome manifested by arthralgia, myalgia, rash, and swelling. Sporadic cases of serum sickness-like reaction have presented shortly after oral minocycline use, manifested by fever, rash, arthralgia, lymphadenopathy and malaise. In symptomatic patients, diagnostic tests should be performed and ARESTIN treatment discontinued.<br> The use of ARESTIN in an acutely abscessed periodontal pocket or for use in the regeneration of alveolar bone has not been studied.<br> The safety and effectiveness of ARESTIN has not been established in immunocompromised patients or in those with coexistent oral candidiasis. Use with caution if there is a predisposition to oral candidiasis.<br> In clinical trials, the most frequently reported nondental treatment-emergent adverse events were headache, infection, flu syndrome, and pain.<br> To report SUSPECTED ADVERSE REACTIONS, contact Bausch Health US, LLC at 1-800-321-4576 or FDA at 1-800-FDA-1088 or <span class="gwd-span-1v6l"><a href="https://fda.gov/medwatch" target="_blank">www.fda.gov/medwatch</a></span>.<br>
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INDICATION
</span><br> ARESTIN® (minocycline HCl) Microspheres, 1mg is indicated as an adjunct to scaling and root planing (SRP) procedures for reduction of pocket depth in patients with adult periodontitis. ARESTIN® may be used as part of a periodontal maintenance program, which includes good oral hygiene and SRP.<br> Click <span class="gwd-span-1v6l"><a href="https://www.arestinprofessional.com/siteassets/pdf/arestin-pi.pdf" target="_blank">here</a></span> for full Prescribing Information.<br>
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STUDY DESIGN DETAILS
</span><br> Based on a 9-month, multi-center, randomized, parallel group study comparing SRP alone (n=250), SRP plus vehicle (n=240), and SRP plus ARESTIN (n=249). ARESTIN or vehicle was administered to all sites with probing depths ≥5mm. Qualitative and quantitative changes in plaque microorganisms have not been demonstrated in subjects with periodontitis using this product.<br> The incidence of adverse events was similar among treatment groups (>3%). The most common adverse events included headache, dental infection, increased periodontitis, tooth sensitivity, tooth caries dental pain, gingivitis and stomatitis.<br> ©2024 Bausch Health Companies Inc. or its affiliates<br class="gwd-br-1om3">ARE.0082.USA.24
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