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<div class="gwd-div-189y gwd-gen-11n1gwdanimation" id="f1_text1">Are you dose adjusting appropriately</div>
<div class="gwd-div-4za0 gwd-gen-1tk2gwdanimation" id="f1_text2">for your LR-MDS patients?</div>
<div class="gwd-div-1vva gwd-gen-8o7zgwdanimation" id="f1_text3">LR-MDS=lower-risk myelodysplastic syndromes.</div>
<div class="gwd-div-1nxk gwd-gen-1nyygwdanimation" id="f1_text4">INDICATION</div>
<div class="gwd-div-1bl8 gwd-gen-1hgagwdanimation" id="f1_line1">REBLOZYL<sup class="line_R">®</sup> (luspatercept-aamt) is indicated for the treatment of </div>
<div class="gwd-div-1ua0 gwd-gen-ruwggwdanimation" id="f1_line2">anemia without previous erythropoiesis stimulating agent use (ESA-</div>
<div class="gwd-div-1jk4 gwd-gen-iktbgwdanimation" id="f1_line3">naïve) in adult patients with very low- to intermediate-risk </div>
<div class="gwd-div-wwue gwd-gen-1s95gwdanimation" id="f1_line4">myelodysplastic syndromes (MDS) who may require regular red </div>
<div class="gwd-div-4hm3 gwd-gen-174vgwdanimation" id="f1_line5">blood cell (RBC) transfusions. </div>
<div class="gwd-div-hbs8 gwd-gen-6kvxgwdanimation" id="f1_line6">REBLOZYL is not indicated for use as a substitute for RBC </div>
<div class="gwd-div-jggk gwd-gen-w4qdgwdanimation" id="f1_line7">transfusions in patients who require immediate correction of </div>
<div class="gwd-div-1srd gwd-gen-3wwjgwdanimation" id="f1_line8">anemia. </div>
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<div class="gwd-div-5yy0 gwd-gen-kl6pgwdanimation" id="f2_text1">Dose adjustments may</div>
<div class="gwd-div-14hl gwd-gen-eyb7gwdanimation" id="f2_text2">optimize patient response<sup class="line_R">1</sup></div>
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<p class="color2 mb-5">IMPORTANT SAFETY INFORMATION</p>
<p class="color1 mb-5">WARNINGS AND PRECAUTIONS</p>
<p><strong>Thrombosis/Thromboembolism</strong></p>
<p class="isi_para">In adult patients with beta thalassemia, thromboembolic events (TEE) were reported in 8/223 (3.6%) of REBLOZYL-treated patients. TEEs included deep vein thrombosis, pulmonary embolus, portal vein thrombosis, and ischemic stroke. Patients with known risk factors for thromboembolism (splenectomy or concomitant use of hormone replacement therapy) may be at further increased risk of thromboembolic conditions. Consider thromboprophylaxis in patients at increased risk of TEE. Monitor patients for signs and symptoms of thromboembolic events and institute treatment promptly.</p><br>
<p><strong>Hypertension</strong></p>
<p class="isi_para">Hypertension was reported in 11.4% (63/554) of REBLOZYL-treated patients. Across clinical studies, the incidence of Grade 3 to 4 hypertension ranged from 2% to 9.6%. In ESA-naïve adult patients with MDS with normal baseline blood pressure, 23 (36%) patients developed SBP ≥140 mm Hg and 11 (6%) patients developed DBP ≥80 mm Hg. Monitor blood pressure prior to each administration. Manage new or exacerbations of preexisting hypertension using anti-hypertensive agents.</p><br>
<p><strong>Embryo-Fetal Toxicity</strong></p>
<p class="isi_para">REBLOZYL may cause fetal harm when administered to a pregnant woman. REBLOZYL caused increased post-implantation loss, decreased litter size, and an increased incidence of skeletal variations in pregnant rat and rabbit studies. Advise pregnant women of the potential risk to a fetus. Advise females of reproductive potential to use effective contraception during treatment and for at least 3 months after the final dose.</p><br>
<p class="color1">ADVERSE REACTIONS</p>
<p class="isi_para">Grade ≥3 (≥2%) adverse reactions included hypertension and dyspnea.
The most common (≥10%) all-grade adverse reactions included diarrhea, fatigue, hypertension, peripheral edema, nausea, and dyspnea.</p><br>
<p class="color1">LACTATION</p>
<p class="isi_para">It is not known whether REBLOZYL is excreted into human milk or absorbed systemically after ingestion by a nursing infant. REBLOZYL was detected in milk of lactating rats. When a drug is present in animal milk, it is likely that the drug will be present in human milk. Because many drugs are excreted in human milk, and because of the unknown effects of REBLOZYL in infants, a decision should be made whether to discontinue nursing or to discontinue treatment. Because of the potential for serious adverse reactions in the breastfed child, breastfeeding is not recommended during treatment and for 3 months after the last dose.</p><br>
<p> <strong class="color1">DRUG ABUSE POTENTIAL</strong> </p>
<p class="isi_para">Abuse: Abuse of REBLOZYL may be seen in athletes for the effects on erythropoiesis. Misuse of drugs that increase erythropoiesis, such as REBLOZYL, by healthy persons may lead to polycythemia, which may be associated with life-threatening cardiovascular complications.</p><br>
<p>Please see full<gwd-taparea id="Click2_PI1" style="font-weight: bold; display: inline;">
<u class="pi_link">Prescribing Information</u></gwd-taparea> for REBLOZYL.</p><br>
<!-- <p href="#" id="ISI_Reblozyl"><strong>Please see full </br> <gwd-taparea id="clickpi1" style="display: inline-block;text-decoration: underline;cursor: pointer;"><u>Prescribing Information</u></gwd-taparea> for REBLOZYL.</strong> </p> -->
<p class="isi_para">
<strong>Reference: 1.</strong> REBLOZYL [US Prescribing Information], Summit, NJ. Celgene Corporation; 2023.
</p>
<p class="isi_para">REBLOZYL<sup>®</sup> and Celgene Corporation are <br>
trademarks of Bristol-Myers Squibb Company. <br>
© 2025 Bristol-Myers Squibb Company.<br>
2007-US-2500022 08/25
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<div class="gwd-div-gd3v" id="Pi_text">See Full Prescribing Information</div>
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<div class="gwd-div-1p69 gwd-gen-11mpgwdanimation" id="f3_text1">Expect to dose adjust<sup class="line_R">1</sup></div>
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